Cosmetic lip surgery may ease facial paralysis, small study suggests

A cosmetic surgery that uses injections of hyaluronic acid to make lips appear fuller could likewise increase the lives of people along with facial paralysis, according to outcomes of a small study by researchers at Johns Hopkins and Stanford universities.

Facial paralysis triggers the two bodily and psychological problems, says Kofi Boahene, M.D., a facial plastic and reconstructive surgeon in the Department of Otolaryngology-Head and Neck Surgery at the Johns Hopkins University School of Medicine and an author of a published report concerning the study appearing June 18 in the diary JAMA Facial Plastic Surgery. “It’s a quite large problem,” he notes, “that can easily occur as a result of stroke, Bell’s Palsy, muscular dystrophy, trauma and birth defects.”

Without lip control, patients struggle along with drooling, consuming and drinking Free of spillage, and making sounds that require fully closing the lips, such as words containing the letters “b” and “p.” Numerous people along with facial paralysis likewise become self-conscious concerning exactly how they look.

Boahene says he stumbled across a feasible role for hyaluronic acid injection while functioning along with a patient along with a then-undiagnosed case of muscular dystrophy. Her face was weak, and she had trouble speaking. To increase her lip muscle tone, he tried the injection and says the effects were immediate. Her face appeared stronger, and her articulation markedly improved.

“To preserve structure, plants fill their leaves and stems along with water,” Boahene says. “It’s a crude analogy, yet injecting the lips along with hyaluronic acid works in a lot the very same way. It tones the tissue surrounding the muscle.”

To test the procedure, Boahene and his collaborators recruited 22 patients (14 women and eight men) along with facial paralysis on one edge of the mouth along along with three patients along with muscular dystrophy that had lost manage of the two sides of the mouth.

Baseline measures of lip tone were performed by having participants place their lips about an instrument that measured tension and took readings from the left, middle, and right sides of the mouth. (The three patients along with muscular dystrophy endured from uniform weakness across the lips, while the rest of the patients had lost manage on one edge only). The researchers after that identified the weakest points by having participants blow air along with pursed lips. At points where air escaped, the researchers injected the hyaluronic acid.

Boahene says the findings were striking, along with the greatest improvement seen in the three patients along with muscular dystrophy, whose lip strength increased six- to sevenfold over the original reading. For participants along with paralysis on only one edge of the mouth, lip strength increased an standard of 1.4-fold on the paralyzed edge and 0.4-fold on the unaffected side.

To see exactly how well those improvements carried over to everyday life needs, a speech therapist conducted a before-and-after assessment of the patients’ ability to speak and to consume and drink Free of spilling. all of 25 patients showed marked improvement, Boahene says. Plans are underway to confirm the benefits in a larger study along with concerning 100 patients.

The effects of the injections, which cost between $500 and $2,000, are temporary, lasting concerning a year once done for cosmetic purposes. once done for cosmetic improvement, insurance usually does not cover the bill. However, insurance companies usually make an exception once the benefits are primarily therapeutic, Boahene says. Lip injection is a minimally invasive outpatient procedure that can easily be performed by dermatologists and plastic surgeons; however, Boahene says, it is vital that therapeutic injections be performed by physicians went through in treating and managing facial paralysis and muscle weakness.

Boahene says that if the 25 patients go on to reveal improvement Free of any kind of marked edge effects, he could pursue examinations of longer-lasting solutions, such as removing fat from elsewhere in the physique and injecting it about the mouth.

Moreover, he says, the procedure might likewise guidance patients whose facial nerves have actually been repaired yet that demand temporary lip guidance while full healing from such repairs occurs.

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The above information is reprinted from materials offered by Johns Hopkins Medicine. Note: contents could be edited for content and length.

Action spectrum of sun skin damage documented

Scientists at Newcastle University have actually documented for the very first time the DNA damage which can easily occur to skin across the complete range of ultraviolet radiation from the sun offering an invaluable device for sun-protection and the manufacturers of sunscreen.

Testing on human skin cell lines, this study published in The Society for Investigative Dermatology, documents the action spectrum of ultraviolet damage in cells derived from the 2 the top layer (dermis) and lesser layer (epidermis) of the skin.

This will certainly permit manufacturers of sunscreen to create and test products to ensure that they can easily give protection to the 2 layers.

Our skin ages as a result of the constant exposure to sunlight as ultraviolet radiation comprising UVA and UVB rays from the sun penetrates cells and boosts the variety of damaging free radicals, especially the reactive oxygen species. also lots of reactive oxygen species can easily be harmful due to the fact that they can easily damage the DNA within our cells.

Over time, this can easily bring about the accumulation of DNA damage, particularly in mitochondria — the batteries of the cells — which rate up aging and ruin the skin’s supportive fibres, collagen and elastin, best to wrinkles. Studies strongly suggest the damage caused by reactive oxygen species might likewise initiate and exacerbate the progression of skin cancers.

Professor Mark Birch-Machin, Professor of Molecular Dermatology at Newcastle University said: “due to the fact that we were able to analyse the complete spectrum of UVA and UVB induced sunburnt DNA damage in the batteries of human skin cells this is an invaluable device for the cosmetic and pharmaceutical industries and for anti-aging studies.”

The Engineering and Bodily Sciences Research Council funded Dr Jennifer Latimer as a CASE PhD Student at Newcastle University for the job alongside a funding award for the collaboration along with Proctor and Gamble.

Dr Latimer said: “It is delightful to believe that four years of scientific research has actually resulted in an outcome that is potentially beneficial, not just to the scientific community however likewise to industry and the total public.”

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The above article is reprinted from materials offered by Newcastle University. Note: contents could be edited for content and length.

PTC Therapeutics to Host Conference Call to Discuss Second Quarter 2015 Financial Results






SOUTH PLAINFIELD, N.J., July 16, 2015 /PRNewswire/ — PTC Therapeutics, Inc. (NASDAQ: PTCT) today announced that the Firm will certainly host a webcast conference call to report its second quarter 2015 financial outcomes and give an update on the company’s company and outlook on Thursday, July 30, 2015 at 4:30 p.m. (ET) after the closing of the market.

The call can easily be accessed by dialing (877) 303-9216 (domestic) or + 1 (973) 935-8152 (international) 5 moments prior to the begin of the call and supplying the passcode 86272093. A live, listen-just webcast of the conference call can easily be accessed on the investor relations section of the PTC website at www.ptcbio.com. A webcast replay of the call will certainly be readily available around 2 hrs after completion of the call and will certainly be archived on the company’s website for 2 weeks.

About PTC Therapeutics, Inc.
PTC is a global biopharmaceutical Firm focused on the discovery, progress and commercialization of orally administered, proprietary small molecule drugs targeting a spot of RNA biology we refer to as post-transcriptional control. Post-transcriptional regulate procedures are the regulatory events that occur in cells throughout and after a messenger RNA is copied from DNA through the transcription process. PTC’s internally found pipeline addresses multiple therapeutic areas, including rare disorders, oncology and infectious diseases. PTC has actually found every one of its compounds currently under progress making use of its proprietary technologies. PTC strategies to keep on to create these compounds the 2 on its own and through selective collaboration arrangements along with best pharmaceutical and biotechnology companies. For a lot more article on the company, please visit our website www.ptcbio.com.

For a lot more Information:

Investors:
Emily Hill
+1 (908) 912-9327
ehill@ptcbio.com

Media:
Jane Baj
+1 (908) 912-9167
jbaj@ptcbio.com

SOURCE PTC Therapeutics, Inc.

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Two techniques of temporal migraine surgery are ‘equally effective’

Two migraine surgery techniques targeting a individual “create site” are the 2 highly efficient in lowering the frequency and severity of migraine headaches, according to a randomized trial in the July issue of Plastic and Reconstructive Surgery®, the official medical diary of the American Society of Plastic Surgeons (ASPS).

Patients along with temporal-type migraine derive similar and considerable improvement from techniques that relieve tension on (decompression) or remove a section of (neurectomy) the nerve responsible for triggering their headaches, reports the study by ASPS Member Surgeon Bahman Guyuron, MD, Emeritus professor of plastic surgery at Case School of Medicine, Cleveland, and colleagues.

Both Approaches efficient for Temporal Migraine Surgery

Dr. Guyuron made the migraine surgery techniques after noticing that some migraine patients had reasonable headache activity after undergoing cosmetic forehead lift procedures. The surgery targets create sites in the nerve branches that develop headaches, identified by preoperative evaluation. create sites are detected using a constellation of symptoms, nerve blocks, ultrasound Doppler and CT scans.

The study included twenty patients along with the temporal sort of migraine headaches — one of both most common create sites. All of had serious and regular migraine attacks despite standard medications. The patients underwent surgery on the 2 sides of the head, targeting the nerve implicated in temporal migraine headaches: the zygomaticotemporal branch of the trigeminal nerve (ZTBTN).

On one side, a decompression procedure was performed to relieve tension placed on the nerve by surrounding tissues. On the others side, a neurectomy procedure was performed, in which a small piece of the nerve was removed. Neurectomy of the ZTBTN has actually long been performed as portion of several plastic and neurosurgery procedures for decades, along with no apparent complications.

To assess the relative effectiveness of both techniques, outcomes were compared between sides one year after surgery. In nearly 90 percent of operated sites, surgery made at least a one-half reduction in migraine frequency, days along with migraine, and headache severity and duration.

The outcomes were almost identical between sides. Migraine frequency decreased from 14.6 to 2.2 per month along with nerve decompression and from 14.2 to 1.9 per month along with neurectomy. Migraine severity (on a ten-point scale) decreased from 7.0 to 2.9 along with decompression and from 6.8 to 2.6 along with neurectomy.

Both techniques additionally reasonable migraine-related disability. There were no complications of either procedure.

Migraine surgery has actually emerged as an efficient option for patients that don’t respond to the limited medication selections for treating migraine headaches. Due to the fact that 2000, Dr. Guyuron and his group have actually published 24 articles in peer-reviewed journals on migraine surgery and its efficacy, along with an additional 12 research projects in process. 5 independent centers have actually confirmed Dr. Guyuron’s findings.

The brand-new trial adds to the evidence by showing that decompression and neurectomy are “just as effective” techniques for treatment of right patients along with temporal migraine headaches. Dr. Guyuron and colleagues conclude, “the 2 procedures can easily be performed safely along with considerable improvement in symptom burden, devoid of concern for excellent morbidity [complications].” They include that patients that don’t grab adequate relief from very first decompression surgery could still incentive from neurectomy as a second option.

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The above short article is reprinted from materials offered by Wolters Kluwer Health: Lippincott Williams and Wilkins. Note: contents could be edited for content and length.

Medical tourism: Implications for patients, health systems

Patients that travel abroad for medical treatment risk returning along with complications or infections that require costly treatment on the NHS and is one of the troubles highlighted in a brand-new handbook exploring medical tourism.

In particular, cosmetic procedures appear a location of growth for medical travel by UK patients, however can easily frequently result in costly intervention as soon as spine home, researchers at the University of York have actually concluded.

It’s estimated that botched cosmetic job overseas costs the NHS £8 million a year.

Medical tourism — individuals taking a trip abroad along with the expressed purpose of accessing medical treatment — is a growing phenomenon associated along with globalization.

This growth has actually been boosted by cheaper air travel and by the Internet, which allows medical providers from one country to market themselves to patients in another.

It is estimated that in 2015 globally 5 million individuals will certainly seek medical treatment abroad.

However, little is known as to which patients go for to travel and why, as soon as others do not.

Researchers from York’s department of Social Policy and Social job and the London School of Hygiene and Tropical Medicine brought with each other a global community of researchers and writers to make the ‘Handbook on Medical Tourism and Patient Mobility’. It is published by Edward Elgar.

One of the handbook’s editors, Dr Neil Lunt, said: “We have actually been aware of a growing worldwide group of scholars that are interested in patients that travel from country for treatment.

“Just what we wanted to do in this handbook was actually to bring with each other every one of the scholars however additionally to concentrate on places and writers that are pretty frequently neglected.

“frequently the focus is on the US and Europe, however there’s crucial points going on about the globe in Africa, Asia, Middle East and South America.”

The handbook explores the emergence of medical tourism and patient mobility and the implications this has actually for patients and healthiness units about the world.

It explores topics such as risk, law and ethics; patient experience and treatment outcomes for cosmetic, transplantation, dental, fertility and fat burning surgery.

The editors conclude that despite a number of studies focusing on UK patients, there has to be further research on the potential impact and costs of medical tourism on the NHS.

Neil Lunt added: “If a person decides to go oversees for cosmetic work, that’s an specific thing they do. however if as soon as they return there’s job that has to be done, that usually gets selected up by the NHS.

“individuals are travelling abroad devoid of necessarily knowing that if goes wrong they are not covered in the same method in terms of redress if they were treated by the NHS or treated privately in the UK. individuals are so used to merely jumping on planes.”

More article can easily be found at: https://www.elgaronline.com/view/9781783471188.xml

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The above short article is reprinted from materials offered by University of York. Note: contents could be edited for content and length.